hrp0097p2-221 | Adrenals and HPA Axis | ESPE2023

Diabetes insipidus as first manifestation of congenital malformation of the neurocranium

Vasiliu Ioana , Frasinariu Otilia , Mocanu Adriana , Daniel Iancu Ionut , Mihaela Trandafir Laura

Central diabetes insipidus (CDI) at neonatal age may occur in the setting of intracranial abnormalities that affect the hypothalamus-pituitary system. These conditions are characterized by defective production, transport or secretion of antidiuretic hormone (ADH). This results in inappropriately low ADH levels in the setting of increased plasma osmolality. We present the case of an infant born by C-section at 38 weeks of gestation, with bilateral cheilognatopalatoschisis, naso...